Anti-aging: A Vital Necessity in Today’s Super-Aged Society!
In recent years, technological advances and improvements in medical care have contributed to an increasing average human lifespan. According to United Nations data from 2021, the global population aged 65 and older is projected to rise from 761 million to 1.6 billion within the next 30 years, nearly doubling. In Taiwan, where medical advancements and declining birth rates are prominent, the proportion of the elderly population is growing each year. By 2025, Taiwan will officially become a super-aged society, with one in every five individuals over the age of 65. However, advancing age does not always mean physical decline. More and more mature individuals are defying the effects of time through proper care and maintenance, preserving their youthfulness to such an extent that one might not guess their true age without seeing an ID. This challenges the traditional perception of the elderly as frail and wrinkled; advanced age can also be vibrant and energetic. As we face the ongoing process of aging, effective health strategies for maintaining youthfulness will be essential for enhancing quality of life!
Revitalize from Within: NMN and NAD+ Precursors Leading the Latest Health Trend!
Introducing the Vital Component NMN!
Numerous wellness supplements have flooded the market, with NMN emerging as one of the most popular ingredients. NMN, a precursor to NAD+, is naturally present in small amounts in foods like broccoli, cucumber, avocado, tomatoes, beef, and shrimp. Animal studies have shown that β-Nicotinamide Mononucleotide (NMN) supplementation can effectively reduce age-related physiological decline.[1] A 2023 human study conducted a 60-day randomized, double-blind trial with 80 healthy middle-aged adults, administering various doses of NMN. This study assessed tolerance, safety, physical performance, blood biological age, and insulin resistance. Results indicated improved physical performance, including increased walking distance and better blood physiological markers, with statistically significant improvements (p<0.05) over the control group.[2]
This promising health ingredient has created a market sensation, prompting various countries to implement specific manufacturing and sales regulations to ensure its safety.
What is NAD+?
The key to maintaining youthful vitality lies in the mitochondria, the cell’s powerhouses, which produce ATP to fuel cellular energy and generate significant amounts of the anti-aging factor NAD+. NAD+ is crucial for cell division and growth. However, with age, oxidizing agents gradually build up in the mitochondria, leading to chromosomal mutations and dysfunction, which can cause mitochondrial breakdown. Reduced NAD+ levels result in lower cellular energy production, leading to a decline in vitality. Beyond supporting mitochondrial energy production, NAD+ activates anti-aging proteins like SIRTs, inhibits the pro-apoptotic protein SARM1, aids in NADP+ synthesis for immune regulation, and supports calcium signaling. NAD+ also significantly influences circadian rhythms and metabolism. Studies show that declining NAD+ levels in muscles, nerve cells, and immune cells are closely linked to aging and disease progression. Thus, the restoration of youth is deeply tied to the regeneration of NAD+.[3]
Where Does NAD+ Come From?[4]
- Preiss-Handler Pathway: Obtaining NA (commonly known as vitamin B3) from food or supplements to produce NAD+.
- De Novo Pathway: Acquiring tryptophan from food or supplements to make NAD+.
- Salvage Pathway: The most efficient and primary synthetic route involves converting NR/NAM, taken from food or supplements, into NMN to produce NAD+.
Beyond NMN! Other NAD+ Booster Supplements Effectively Reshape Health
Recent studies have shown that resveratrol can enhance the activity of the NAD+ synthesizing enzyme Nicotinamide Mononucleotide Adenyltransferase (NMNAT1), thereby increasing NAD+ levels.[5]
A 2022 randomized, triple-blind, placebo-controlled crossover clinical trial demonstrated that a combination of NAD+ booster supplements-NAM and D-ribose- can safely and effectively elevate NAD+ levels in healthy middle-aged individuals. When administered twice daily for 5 days, participants showed a significant increase in blood NAD+ concentrations compared to the placebo group, including a notable 27% rise in NADP+ (p=0.033), leading to improvements in fatigue, focus, and proactivity. This suggests that NMN is not the only option; consuming various NAD+ precursors or regulatory substances can effectively reverse NAD+ depletion in the body.
Due to the large molecular size of NAD+, direct supplementation is ineffective. Instead, small-molecule precursors like NMN and NAM are preferred for boosting NAD+ levels in the body. WelBloom Biotech is well-versed in the regulatory frameworks for health food sales in various countries and maintains a database of over ten thousand formulations. This allows for the flexible use of different NAD+ booster supplements in products. Depending on the health claims of each supplement, complementary ingredients are combined in customized formulas to enhance effectiveness!
[1]Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
https://pubmed.ncbi.nlm.nih.gov/28068222/
[2]The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial
https://pubmed.ncbi.nlm.nih.gov/36482258/
[3]The Role of NAD+ in Regenerative Medicine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512238/
[4]Targeting NAD Metabolism for the Therapy of Age-Related Neurodegenerative Diseases
https://link.springer.com/article/10.1007/s12264-023-01072-3
[5]Resveratrol Increases Intracellular NAD+ Levels Through Up regulation of The NAD+ Synthetic Enzyme Nicotinamide Mononucleotide Adenylyltransferase
https://www.nature.com/articles/npre.2010.4421.1
